Angela Creager

How does scientific knowledge inform regulation of toxic substances—or not? Creager seeks to answer this question through the history of one widely-used toxicity test, known as Ames test (after its inventor), which was developed in 1973 as a quick and easy way to identify substances that cause genetic mutation. The idea behind this test—that cancers are caused by mutations—remains the major framework for cancer biology to this day. Yet the US federal statute aimed at regulating all commercial chemicals, which was signed into law in 1976 after the Ames test became available, did not require that new (or old) chemicals be tested for whether they cause mutations. By contrast, pharmaceutical companies took up the Ames test uniformly in screening potential drugs. Her research probes the scientific, political, and legal reasons for uneven requirements in the testing of chemicals. In doing so, she expands our understanding of regulatory decision-making to include materials and scientific practices. She also examines how these regulatory tools were taken up by international organizations harmonizing toxicology test standards in the 1970s and beyond.

Jean-Paul Gaudillière (EHESS, Cermes3), Soraya Boudia (EHESS, Université de Paris-Descartes, Cermes3), and Angela Creager will be organizing a collaborative project on environmental health in a globalizing world. They are especially interested in why concerns about health problems from resource extraction and industrialization were so slow to be taken up by advocates of global health. This project will pay attention to how different international institutions and the private sector vied for authority over commercial chemicals, toxic waste, and safety data.